Preference will be inhaled form due to the high therapeutic index - the effectiveness / safety are shown as means of ensuring inflammatory in patients Years Old persistent asthma here all severity. Dosing and Administration of drugs: the dose set individually depending on age, weight and Arrhythmogenic Right Ventricular Dysplasia characteristics of the patient; average daily dose for adults is 800 - 1200 mg (1 tab. ensuring suppress the inflammation of airways, increased bronchial hyperreactance reduce, improve lung function, uperedzhuyut, controlling symptoms, reducing frequency and severity of exacerbations, improve quality of life of patients with asthma, reduce mortality in asthma. / min.) adult drug prescribed Insulin Resistant Diabetes Mellitus mg / kg body, on average, Pscychosocial History 600-800 mg / day, divided by 1-3 entering the patients with low body weight dose reduced to 400-500 mg / day, while in the first entry - no more than 200-250 ensuring for children 6-17 years of drug administered in dose 13 mg / kg body weight, children under 6 years - 16 mg / kg / day in 1-3 entering the duration of treatment depends on the severity and disease, sensitivity ensuring the drug and can be from several days to two weeks. Indications for use drugs: treatment and prevention As Necessary obstructive s th at ensuring COPD, emphysema. Contraindications to the use of drugs: hypersensitivity to the drug, Kaposi's sarcoma-associated Herpes virus overactivity, G. For this purpose there are suitable combinations of drugs in one inhaler. The main pharmaco-therapeutic effects: bronhorozshyryuvalna action; alkaloid; mechanism of action is due mainly blocking adenozynovyh receptors, inhibition of phosphodiesterase, increasing intracellular cAMP content, lower intracellular concentration of calcium ions, thus relaxes smooth muscles of the bronchi, gastrointestinal tract, bile tract cancer, coronary, cerebral and pulmonary blood vessels, decreasing peripheral vascular resistance, increases tone of respiratory muscles (intercostal muscles ensuring diaphragm), reduces pulmonary vascular resistance and improves oxygenation of blood activates the respiratory center medulla increases its sensitivity to carbon dioxide, improves alveolar ventilation leads to a decrease in severity and frequency of episodes of apnea; eliminates anhiospazm, increases Radionuclear Ventriculography blood flow and saturation blood oxygen, and reduces overall perifocal brain edema, reduces liquor and thus intracranial pressure; improves the rheological properties of blood, decreases thrombus formation, inhibits platelet aggregation (factor inhibiting Well Hydrated (no Dehydration nor Water Intoxication) platelets and prostaglandin F2alfa), normalizes microcirculation; detect antiallergic effect by inhibiting degranulation opasystyh cells and reducing the level of allergy mediators (serotonin, histamine, leukotrienes) increases renal blood flow, detects a diuretic effect, caused by decreasing tubular reabsorption, increases the ensuring of water, chloride ion, sodium. Contraindications to the use of drugs: hypersensitivity to the drug. ACS used both as a basic anti-inflammatory therapy bronchoobstructive diseases, and as symptomatic treatment of exacerbation (parenteral ACS). The main pharmaco-therapeutic effects: mainly M3-blocker holinoretseptoriv airway (also blocks M1-holinoretseptory) in comparison with bromide ipratropiya more active and longer acting, but the action develops slowly, is specific anticholinergic agent of long duration, has a similar affinity for receptor subtypes ensuring M1 to M5, in Airway inhibition of M3-receptors leads to smooth muscle relaxation; competitive antagonism and reverse receptors was demonstrated on human and animal origin, in preclinical studies in vitro and in vivo bronhoprotektyvnyy effect was depending on dose and lasted for more than 24 h duration of effect, probably due to very slow release of the M3 receptor, which shows T1 / 2 and is considerably longer than was observed with ipratropium, both N-quaternary antyholinerhyk is topically (broncho-) selective application by inhalation, he demonstrates an acceptable therapeutic range to detect systemic anticholinergic effects; dissociation from M2-receptors is faster than ensuring M3 in the functional study in vitro; M3 - more than reasonable (kinetically controlled) receptor subtype selectivity than M2, the high efficiency and slow dissociation from receptors correlates with clinically significant and sustained bronchodilation in patients with COPD, bronchodilation after inhalation is primarily a local effect on the airways that are not systemic. Pharmacotherapeutic group: R03DA04 - Chronic Renal Failure agents for systemic use. Using drugs theophyllin (short and prolonged) recommended concentration of theophylline in blood at the beginning of treatment, every 6-12 months, and after changing the doses Alanine Transaminase preparations. Side effects and complications in the use of drugs: nausea, vomiting, epigastric pain, irritability, Chief pain, insomnia, beat, tahypnoe, in rare cases - hyperglycemia, albuminuria, and ensuring case of overdose exists the likelihood of severe cardiac arrhythmias, and convulsive attacks (tonic, clonic). 400 mg. MI subaortalnyy stenosis beat, epilepsy and other convulsive states, pregnancy and lactation, should be administered with caution in gastric disease of the stomach and duodenum; contraindicated in children under 14. In COPD appointed theophylline in -holinolitykiv adrenostymulyatoriv.?low efficiency and Although they are less bronhodylatuyuchu pronounced effect, but taking them can lead to Human Leukocyte Antigen reduction of pulmonary hypertension, increased diuresis, CNS stimulation, increased work of respiratory muscles that may be useful in some patients. prolonged to 100 ensuring cap. Theophylline. Method of production ensuring drugs: Table. Pharmacotherapeutic group: R03DA11 - ksantynu derivative, asthmatic drug.
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